Real Madrid - Juventus Prediction - UEFA Champions League, October 22, 2025
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Real Madrid host Juventus on October 22, 2025 at the Santiago Bernabeu in Madrid with the kick-off at 22:00. The hosts lead La Liga with 21 points from eight games and 19 goals scored this season, while the visitors are 5th in Serie A on 12 points from six and have drawn five on the spin across competitions. Madrid are 2–0–0 in the UCL league phase with a 7:1 goal difference after beating Marseille (2–1) and Kairat (5–0). Juventus have drawn both their league
phase matches – 4–4 vs Dortmund and 2–2 at Villarreal – for a 0–2–0 start (6:6 GD). In the last eleven head
to
head meetings Madrid have six wins to Juve’s three (two draws). With five straight UCL home wins at the Bernabeu, Madrid look slightly more likely to edge a close contest.

Forms of the Teams

Real Madrid

Team is strong domestically under Xabi Alonso. Despite injuries, the defense allows only around a goal per game. In Europe they have two wins from two and their recent run reads six wins in seven. Madrid generally controls midfield through Tchouameni and Valverde, press high to force turnovers and at home in the UCL have scored seven goals across their last three ties while averaging roughly 60–62% possession.

Juventus

Igor Tudor’s side mix results but remain hard to beat. In the UCL they have two draws from two, and away in Europe they’ve won one of their last four. Tudor prefers counterattacks, which helps explain a sequence heavy on stalemates, while Yildiz’s recent goals underline how much they rely on him. Form is steady but they are winless in three straight road matches.

Predicted Lineups

Real Madrid Lineup

Predicted formation: 4-3-3
  • Goalkeeper:
    Courtois
  • Defense:
    Valverde, Huijsen, Alaba, Fran Garcia
  • Midfield:
    Tchouameni, Camavinga, Bellingham
  • Forwards
    : Rodrygo, Mbappe, Vinicius

Juventus Lineup

Predicted formation: 3-4-2-1
  • Goalkeeper:
    Di Gregorio
  • Defense:
    Gatti, Bremer, Kelly
  • Midfield:
    Cambiaso, Locatelli, McKennie, Thuram
  • Forwards:
    Vlahovic with Yildiz and Conceicao operating behind

Who Will Miss Out

Real Madrid still have defensive concerns. Rudiger is out with a thigh injury, Carvajal faces roughly four weeks on the sidelines with a calf strain, Militao is returning from an ankle issue and could start on the bench and Mendy is still working back from a muscular problem. Alexander-Arnold has been managing a hamstring problem but is nearing full fitness, while Mbappe is fit after a minor ankle knock.
Juventus are lighter in midfield with Miretti sidelined by a muscle issue and Conceicao recently a doubt with a minor leg problem. Milik remains a long
term absentee after knee and subsequent setbacks. Thuram is available again after a rest and Bremer has been cleared; Locatelli will be key in the center. No major forward losses beyond rotation choices between Vlahovic and David.

Main Prediction for Real Madrid vs Juventus

Real Madrid are justified favorites at home with the Mbappe–Vinicius axis giving them sustained threat and an average of around 2.7 goals in recent matches, while Juventus draw frequently away. The head-to-head stands at Madrid six wins, Juventus three and two draws and although injuries affect both squads.

Prediction 1: 
Real Madrid to win at 1.55 looks playable.

With an expected 58% possession share for the hosts, Vinicius should keep stretching the flanks, Juventus often fade after the hour mark and Madrid have won four of their last five UCL home games.

Prediction 2: 
Both teams to score at 1.70 is also reasonable.

Since Juventus can nick one on the break with Yildiz exploiting gaps, Madrid have conceded in five of their last seven and the combined trend points to roughly 2.9 total goals on average.
All odds are according to the date of this prediction. Check out much more information in the sports section of Batery Bets.
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